First , published on November 19 , 2010 as 10 . 1136 / adc . 2010 . 190975
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چکیده
Aim To examine transaminitis in obese children, its association with glucose metabolism and the metabolic syndrome and the response to weight loss through lifestyle modifi cation. Methods 216 children (90 male), aged 2.9–17.6 (median 12.4 years) with median body mass index (BMI) SD score (SDS) of 3.36 (range 1.92–6.22) attending a hospital obesity clinic in Bristol (UK) underwent an oral glucose tolerance test (OGTT) with fasting lipid and liver profi le. Auxological measures included weight, height, waist circumference, percentage body fat. Parental history of type 2 diabetes (T2DM) was recorded. The 2007 International Diabetes Federation defi nition of metabolic syndrome was used. 90 children undergoing a trial of lifestyle modifi cation to improve weight were reassessed at 12 months. Results 34/216 (16%) children had raised alanine amin-otransferase (ALT) (>40 IU/l) with greater prevalence in boys (23% vs 10%, p=0.01) and in those with a parental history of T2DM (30% vs 13.2% p=0.019). Patients with transaminitis were more likely to fulfi l the criteria for metabolic syndrome (p<0.001) and have subtle abnormalities in glucose metabolism during an OGTT with elevated glucose levels at 90 (p=0.041) and 120 (p=0.014) min and a greater glucose area-under-the-curve (p=0.014). Improvement in BMI SDS over 1 year correlated with improvement in ALT levels (τ = −0.29, p<0.001). Conclusion Prevalence of transaminitis is signifi cant in obese children and is associated with components of the metabolic syndrome. Lifestyle-based improvement in BMI SDS offers an effective tool for correcting transaminitis and should remain the central component of therapy.
منابع مشابه
ADC Online First , published on February 13 , 2011 as 10 . 1136 / adc . 2010 . 204552
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http://adc.bmj.com/content/early/2010/06/24/adc.2010.190637.full.html Updated information and services can be found at: These include: References http://adc.bmj.com/content/early/2010/06/24/adc.2010.190637.full.html#ref-list-1 This article cites 5 articles, 1 of which can be accessed free at: P<P Published online June 24, 2010 in advance of the print journal. service Email alerting box at the t...
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From Hospital Epidemiology, University of North Carolina Health Care (both authors), and the Division of Infectious Diseases, University of North Carolina School of Medicine (both authors), Chapel Hill, North Carolina. Received November 9, 2009; accepted November 19, 2009; electronically published January 6, 2010. 2010 by The Society for Healthcare Epidemiology of America. All rights reserved. ...
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تاریخ انتشار 2010